Recent Insertion of an Alu Element Within a Polymorphic Human-Specific Alu Insertion
نویسندگان
چکیده
منابع مشابه
Recent insertion of an Alu element within a polymorphic human-specific Alu insertion.
Alu elements are a family of short interspersed repeats that have mobilized throughout primate genomes by retrotransposition over the past 65 Myr of primate evolution (for a review, see Deininger and Batzer 1993). In the human genome, Alu elements exist in copy numbers of approximately 500,000 per haploid genome, representing approximately 5% of the genome, and they may be classified into group...
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Alu insertion polymorphisms are widely distributed in the human genome. They are readily analysed and provide an interesting set of markers for human population genetic and forensic studies. The aim of this article is to present preliminary results from our ongoing project on a survey of Alu insertion polymorphisms in various human populations. INTRODUCTION Repetitive DNA sequences comprise a s...
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A polymorphic Alu element belonging to the young Ya5 subfamily of Alu repeats located in the progesterone receptor gene has been characterized. Using a polymerase chain reaction (PCR)-based assay, the genetic diversity associated with the PROGINS Alu repeat was determined in a diverse array of human populations. The level of insertion polymorphism associated with PROGINS suggests that it will b...
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A member of the Alu family of repeated DNA elements has been identified on the long arm of the human Y chromosome, Yq11. This element, referred to as the Y Alu polymorphic (YAP) element, is present at a specific site on the Y chromosome in some humans and is absent in others. Phylogenetic comparisons with other Alu sequences reveal that the YAP element is a member of the polymorphic subfamily-3...
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Short INterspersed Elements (SINEs) make very useful phylogenetic markers because the integration of a particular element at a location in the genome is irreversible and of known polarity. These attributes make analysis of SINEs as phylogenetic characters an essentially homoplasy-free affair. Alu elements are primate-specific SINEs that make up a large portion of the human genome and are also w...
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ژورنال
عنوان ژورنال: Molecular Biology and Evolution
سال: 2001
ISSN: 1537-1719,0737-4038
DOI: 10.1093/oxfordjournals.molbev.a003722